Thanks for pointing out this project!
Out of my research here is what I found:
- Blog posts:
- Grant Milestones:
- Repository: GitHub - philoniare/subxtpy: Interact with Substrate based nodes in Rust or WebAssembly using Python
- on PyPI
subxtpydocumentation
This project has a potential! Right now, it seems unknown from the community, since I am the first one starring it on GH, and there are no issue nor PR. philoniaire did set up the first bricks against remunerations, but, no community took over this project. If the project ever gets or is unmaintained, problems could begins.
I had an issue with a Python library using Rust which still does not support Python 3.13. Currently subxtpy does not support Python 3.13. That’s not the case with a full-Python library, which usually support next minor Python version out-of-the-box, except required minor code changes regarding deprecations. On the other hand, Python library based on Rust code, requires more efforts to support next Python minor version.
The project also has to create a new release to publish wheels with built code on PyPI, to support new Python versions. That’s one disadvantage for using compiled languages in Python libraries. The advantage is of course speed. In the end, these criteria falls into maintenance topics.
These are my fears. But yeah, that’s good to have a second choice! Two Python libraries 
@vit one aspects you might not like about subxtpy is that it forces the asynchronism property usage.